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《武汉工程大学学报》| 陈思雨 等:环糊精在制药技术中的应用

  • 2026-10-08 20:44:40
《武汉工程大学学报》| 陈思雨 等:环糊精在制药技术中的应用

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中文摘要：

一些候选药物水溶性差导致生物利用度低，成为新药研发的障碍。本综述首先描述了环糊精从天然产物中纯化和分离的过程，由于其安全性高被广泛用于制药工业。其次介绍了环糊精内部疏水外部亲水的独特结构，可以通过主客体相互作用与难溶性药物形成包合物，在不改变分子结构的情况下改善药物的稳定性、溶解度和生物利用度。然后，针对药物的不同属性，讨论了环糊精包合物的制备方法、适用范围及其优缺点。最后总结了环糊精在制药领域方面的最新应用案例，及其药代动力学和毒理学数据。

关键词：

环糊精；包合物；溶解度；稳定性；主客体作用

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